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| Adenosine receptor A3 ： ウィキペディア英語版 |
Adenosine A3 receptor
The adenosine A3 receptor, also known as ADORA3, is an adenosine receptor, but also denotes the human gene encoding it.
== Function ==
Adenosine A3 receptors are G protein-coupled receptors that couple to Gi/Gq and are involved in a variety of intracellular signaling pathways and physiological functions. It mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death.
Recent publications demonstrate that adenosine A3 receptor antagonists (SSR161421) could have therapeutic potencial in bronchial asthma (17,18).
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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